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    Aspirin reduces obesity cancer risk

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    yoly
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    Aspirin reduces obesity cancer risk

    Post by yoly on Tue Aug 18 2015, 11:09

    Published Monday 17 August 2015

    Research has shown that a regular dose of aspirin reduces the long-term risk of cancer in those who are overweight.

    Researchers found that being overweight more than doubled the risk of bowel cancer in people with Lynch Syndrome, an inherited genetic disorder which affects genes responsible for detecting and repairing damage in the DNA. Around half of these people develop cancer, mainly in the bowel and womb.

    However, over the course of a ten year study they found this risk could be counteracted with a regular dose of aspirin.

    Professor Tim Bishop, from the School of Medicine at the University of Leeds, led the statistical analysis for the research. He said: “Our study suggests that the daily aspirin dose of 600 mg per day removed the majority of the increased risk associated with higher body mass index (BMI). However, this needs to be shown in a further study to confirm the extent of the protective power of the aspirin with respect to BMI.”

    Professor Sir John Burn, Professor of Clinical Genetics at Newcastle University who led the international research collaboration, said: “This is important for people with Lynch Syndrome but affects the rest of us too. Lots of people struggle with their weight and this suggests the extra cancer risk can be cancelled by taking an aspirin.

    “This research adds to the growing body of evidence which links an increased inflammatory process to an increased risk of cancer. Obesity increases the inflammatory response. One explanation for our findings is that the aspirin may be supressing that inflammation which opens up new avenues of research into the cause of cancer.”

    The international study of people with a family history of the disease, conducted by researchers at the University of Leeds and Newcastle University, is published today in the Journal of Clinical Oncology.

    The randomised controlled trial was part of the CAPP 2 study involving scientists and clinicians from over 43 centres in 16 countries which followed nearly 1,000 patients with Lynch Syndrome, in some cases for over 10 years.

    937 people began either taking two aspirins (600 mg) every day for two years or a placebo. When they were followed up ten years later, 55 had developed bowel cancers and those who were obese were more than twice as likely to develop this cancer – in fact 2.75 times as likely. Following up on patients who were taking two aspirins a day revealed that their risk was the same whether they were obese or not.

    The trial was overseen by Newcastle Hospitals NHS Foundation Trust and funded by the UK Medical Research Council, Cancer Research UK, the European Union and Bayer Pharma.

    Professor John Mathers, Professor of Human Nutrition at Newcastle University, who led this part of the study said: “For those with Lynch Syndrome, we found that every unit of BMI above what is considered healthy increased the risk of bowel cancer by 7%. What is surprising is that even in people with a genetic predisposition for cancer, obesity is also a driver of the disease. Indeed, the obesity-associated risk was twice as great for people with Lynch Syndrome as for the general population.

    “The lesson for all of us is that everyone should try to maintain a healthy weight and for those already obese the best thing is to lose weight. However, for many patients this can be very difficult so a simple aspirin may be able to help this group.”

    However, Professor Burn advised: “Before anyone begins to take aspirin on a regular basis they should consult their doctor as aspirin is known to bring with it a risk of stomach complaints including ulcers.

    “But if there is a strong family history of cancer then people may want to weigh up the cost-benefits particularly as these days drugs which block acid production in the stomach are available over the counter.”

    The international team are now preparing a large-scale follow-up trial and want to recruit 3,000 people across the world to test the effect of different doses of aspirin. The trial will compare two aspirin a day with a range of lower doses to see if the protection offered is the same.

    Information on the next trial can be found at www.capp3.org

    http://www.leeds.ac.uk/news/article/3742/aspirin_reduces_obesity_cancer_risk
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    chris c
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    Re: Aspirin reduces obesity cancer risk

    Post by chris c on Tue Aug 18 2015, 18:59

    I wonder if it's the obesity itself, or high BG, or high insulin, or all of the above.

    Small warning about aspirin though, some years back when I had a not-quite-frozen shoulder I found aspirin was giving me tinnitus. Ibruprofen was similar though not so bad, even the ointment.

    Since then I've avoided it, until it was recently prescribed for CVD. Even the low dose stuff brought back the tinnitus which is now permanent. The GP and hospital doctor are both adamant I should continue with it though. I said "sorry you'll have to speak up"

      Current date/time is Fri Jun 23 2017, 04:31