The Low Carb Diabetic

Promoting a low carb high fat lifestyle for the safe control of diabetes. Eat whole fresh food, more drugs are not the answer.

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    Information Update - Forxiga, Invokana:


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    Information Update - Forxiga, Invokana:

    Post by graham64 on Tue Jun 23 2015, 23:09

    Health Canada begins safety review of diabetes drugs known as SGLT2 inhibitors and risk of ketoacidosis

    OTTAWA, June 22, 2015 /CNW/ - Health Canada initiated a safety review for the prescription diabetes drugs dapagliflozin (Forxiga) and canagliflozin (Invokana) and the risk of ketoacidosis, a serious condition that leads to high levels of blood acids called ketones.

    Dapagliflozin and canagliflozin are known as SGLT2 (sodium-glucose cotransporter-2) inhibitors and are approved in Canada for use in patients with type 2 diabetes to improve blood sugar levels, along with diet and exercise.  

    Ketoacidosis predominantly develops in people with type 1 diabetes when insulin levels are too low, and is associated with high blood sugar levels. There have been international reports of ketoacidosis with the use of SGLT2 inhibitors in patients with type 2 diabetes who had only slightly increased blood sugar levels.

    Because ketoacidosis is unexpected and can appear with only slightly increased blood sugar levels in people with type 2 diabetes, it is possible it may not be quickly identified or treated.

    A preliminary search of Health Canada's adverse reaction database identified one report of diabetic ketoacidosis involving the hospitalization of a 56-year old male taking an SGLT2 inhibitor. The patient was taking other medications at the time and further assessment will be conducted.

    Health Canada will review the available information and will determine whether changes are needed in the prescribing information for this class of drugs. Health Canada will communicate the results of its review once it is complete. While the review is progressing, Health Canada is advising Canadians of this potential risk and encouraging them to report adverse reactions to Health Canada.

    What you should do:

    Symptoms of ketoacidosis include difficulty breathing, feeling very thirsty, vomiting, abdominal pain, nausea, loss of appetite, confusion, and unusual tiredness. Seek urgent medical attention if you think you have these symptoms.
    You should not stop treatment with Forxiga or Invokana without first consulting a healthcare professional. 
    Talk to your doctor or pharmacist if you have any concerns about your diabetic treatment.
    Additional information for healthcare professionals

    Evaluate patients with type 2 diabetes taking an SGLT2 who show signs of diabetic ketoacidosis regardless of blood sugar levels.

    Treatment with an SGLT2 inhibitor should be discontinued if acidosis is confirmed, and appropriate measures should be taken to treat the acidosis and monitor sugar levels.

    But don't worry folks according to a DCUK moderator (cherub) life threatening DKA is "Just something to be aware of not to be alarmed..."

    I'm a skinny T2 diagnosed 4/4/2008, a high calorie LCHF diet and one metformin a day A1c 6.2 and no complications.

    Proving the LowCarb sceptics wrong for over ten years

    Not all cherubs are Angels  Wink nor all diabetics Bonkers  Rolling Eyes

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    Re: Information Update - Forxiga, Invokana:

    Post by Eddie on Wed Jun 24 2015, 08:08

    When you consider how inefficient almost all type two drugs are it makes you wonder why people bother, especially in the many countries people are having to pay for them up front. Then when you consider almost all carry very serious side effects that have effected many people they are not worth the risk in my opinion.

    It borders on lunacy to me, people will take these risks when a change of diet and lifestyle can achieve so much more with absolutely zero risk. Obviously some diabetics have no choice they have to use insulin, but again the benefits of the right diet and minimal insulin use are well proven.

    For years a small group have vilified the low carb diet at the flog, knowing full well without low carb people would have to rely on medication proved to carry risks. The question for me has always been why? one thing is a fact, many of these drug pushers have been made mods and over a year ago the DCUK management stated publicly they were looking for a tie in with big pharma. Also, they have stated publicly on their main site they can supply information to big pharma re. people for drug trials, for a price. This was included in a resent email to the members as reported here.

    Type two diabetic-low carb diet (50 carbs per day) and two 500mg Metformin pills per day. Apart from diagnosis HbA1c almost 12-all HbA1c results none diabetic. For over eight years my diabetes medication has not changed. My weight has remained stable, I have suffered no ill effects from my diet whatsoever. Every blood test has proved, I took the right road to my diabetic salvation. For almost seven years, I have asked medical professionals and naysayers, how do I maintain non diabetic BG levels on two Metformin other than low carb ? The silence has been deafening !

      Current date/time is Tue May 22 2018, 18:52